Recovering Lost Therapeutic Opportunities in High-Risk Paediatric Cancer-Novel Drivers of Receptor Tyrosine Kinase Activation

A novel TRKB-activating internal tandem duplication characterizes a new mechanism of receptor tyrosine kinase activation

LM Brown, G Tax, P Acera Mateos, A de Weck, S Foresto, T Robertson, F Jalud, P Ajuyah, P Barahona, J Mao, MEM Dolman, M Wong, C Mayoh, MJ Cowley, LMS Lau, T Sadras, PG Ekert

2025-12-01

Precision medicine programs like the Zero Childhood Cancer Program perform comprehensive molecular analysis of patient tumors, ena..

PDGFRA in paediatric high-grade glioma – target or distraction?

N Le, J Chen, PG Ekert, LM Brown, N Manoharan

2025-11-01

Paediatric high-grade gliomas (pHGGs) are aggressive and molecularly heterogenous paediatric brain tumours with extremely poor sur..

Principles of CRISPR-Cas13 mismatch intolerance enable selective silencing of point-mutated oncogenic RNA with single-base precision

C Shembrey, R Yang, J Casan, W Hu, H Chen, GJ Singh, T Sadras, K Prasad, J Shortt, RW Johnstone, JA Trapani, PG Ekert, M Fareh

2024-12-20

Single-nucleotide variants (SNVs) are extremely prevalent in human cancers, although most of these remain clinically unactionable...